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bioRxiv · 10.1101/316406

Genetic incompatibility combined with female-lethality is effective and robust in simulations of Aedes aegypti population control

Maselko, M.·Heinsch, S. C.·Das, S.·Smanski, M. J.
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Abstract

Recent reports of CRISPR/Cas9-based suppression gene drives in insects underscore the challenge of overcoming genetic resistance. Here we present results from agent-based simulation modeling of a novel Field-Amplified Male Sterility System (FAMSS) that outperforms suppression gene drives when challenged with genetic resistance. FAMSS combines a recently described synthetic genetic incompatibility approach with previously demonstrated female-lethality constructs. Our results suggest that FAMSS will be an effective strategy for temporally and spatially self-limited suppression of the disease vectoring mosquito, Aedes aegypti.

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Maselko, M., Heinsch, S. C., Das, S., Smanski, M. J.. 2018-05-07. Genetic incompatibility combined with female-lethality is effective and robust in simulations of Aedes aegypti population control. https://doi.org/10.1101/316406

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