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bioRxiv · 10.1101/312587

Excitable dynamics of NREM sleep: a unifying model for neocortex and hippocampus

Levenstein, D.·Buzsaki, G.·Rinzel, J.
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Abstract

During non-rapid eye movement (NREM) sleep, the neocortex and hippocampus alternate between periods of neuronal spiking and inactivity. By directly comparing experimental observations with a mean field model of an adapting, recurrent neuronal population, we find that the neocortical alternations reflect a dynamical regime in which a stable active state is interrupted by transient inactive states (slow waves) while the hippocampal alternations reflect a stable inactive state interrupted by transient active states (sharp waves). We propose that during NREM sleep, hippocampal and neocortical populations are excitable: each in a stable state from which internal fluctuations or external perturbation can evoke the stereotyped population events that mediate NREM functions.

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Levenstein, D., Buzsaki, G., Rinzel, J.. 2018-05-02. Excitable dynamics of NREM sleep: a unifying model for neocortex and hippocampus. https://doi.org/10.1101/312587

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