Reliable individual differences in fine-grained cortical functional architecture

Feilong, M.; Nastase, S. A.; Guntupalli, J. S.; Haxby, J. V.

doi:10.1101/296012

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bioRxiv · 10.1101/296012

Reliable individual differences in fine-grained cortical functional architecture

Feilong, M.·Nastase, S. A.·Guntupalli, J. S.·Haxby, J. V.

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Abstract

Fine-grained functional organization of cortex is not well-conserved across individuals. As a result, individual differences in cortical functional architecture are confounded by topographic idiosyncrasies--i.e., differences in functional-anatomical correspondence. In this study, we used hyperalignment to align information encoded in topographically variable patterns to study individual differences in fine-grained cortical functional architecture in a common representational space. We characterized the structure of individual differences using three common functional indices, and assessed the reliability of this structure across independent samples of data in a natural vision paradigm. Hyperalignment markedly improved the reliability of individual differences across all three indices by resolving topographic idiosyncrasies and accommodating information encoded in spatially fine-grained response patterns. Our results demonstrate that substantial individual differences in cortical functional architecture exist at fine spatial scales, but are inaccessible with anatomical normalization alone.

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Feilong, M., Nastase, S. A., Guntupalli, J. S., Haxby, J. V.. 2018-04-06. Reliable individual differences in fine-grained cortical functional architecture. https://doi.org/10.1101/296012

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