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bioRxiv · 10.1101/287367

Cryo-EM structure of the polycystin 2-l1 ion channel

Hulse, R. E.·Li, Z.·Huang, R. K.·Zhang, J.·Clapham, D. E.
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Abstract

We report the near atomic resolution (3.1 [A]) of the polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.

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Hulse, R. E., Li, Z., Huang, R. K., Zhang, J., Clapham, D. E.. 2018-03-22. Cryo-EM structure of the polycystin 2-l1 ion channel. https://doi.org/10.1101/287367

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