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bioRxiv · 10.1101/285338

Immuno-genomic PanCancer Landscape Reveals Diverse Immune Escape Mechanisms and Immuno-Editing Histories

Mizuno, S.·Yamaguchi, R.·Hasegawa, T.·Hayashi, S.·Fujita, M.·Zhang, F.·Koh, Y.·Lee, S.-Y.·Yoon, S.-S.·Shimizu, E.·Komura, M.·Fujimoto, A.·Nagai, M.·Kato, M.·Liang, H.·Miyano, S.·Zhang, Z.·Nakagawa, H.·Imoto, S.
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Abstract

Immune reactions in the tumor micro-environment are one of the cancer hallmarks and emerging immune therapies have been proven effective in many types of cancer. To investigate cancer genome-immune interactions and the role of immuno-editing or immune escape mechanisms in cancer development, we analyzed 2,834 whole genomes and RNA-seq datasets across 31 distinct tumor types from the PanCancer Analysis of Whole Genomes (PCAWG) project with respect to key immuno-genomic aspects. We show that selective copy number changes in immune-related genes could contribute to immune escape. Furthermore, we developed an index of the immuno-editing history of each tumor sample based on the information of mutations in exonic regions and pseudogenes. Our immuno-genomic analyses of pan-cancer analyses have the potential to identify a subset of tumors with immunogenicity and diverse background or intrinsic pathways associated with their immune status and immuno-editing history.

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Mizuno, S., Yamaguchi, R., Hasegawa, T., Hayashi, S., Fujita, M., Zhang, F., Koh, Y., Lee, S.-Y., Yoon, S.-S., Shimizu, E., Komura, M., Fujimoto, A., Nagai, M., Kato, M., Liang, H., Miyano, S., Zhang, Z., Nakagawa, H., Imoto, S.. 2018-03-20. Immuno-genomic PanCancer Landscape Reveals Diverse Immune Escape Mechanisms and Immuno-Editing Histories. https://doi.org/10.1101/285338

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