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bioRxiv · 10.1101/277996

Genetic and environmental influence on the human functional connectome

Reineberg, A. E.·Hatoum, A. S.·Hewitt, J. K.·Banich, M. T.·Friedman, N. P.
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Abstract

Detailed mapping of genetic and environmental influences on the functional connectome is a crucial step toward developing intermediate phenotypes between genes and clinical diagnoses or cognitive abilities. We analyze resting-state data from two, adult twin samples - 390 twins from the Colorado Longitudinal Twin Sample and 422 twins from the Human Connectome Project - to examine genetic and environmental influence on all pairwise functional connections between 264 brain regions (~35,000 functional connections). Non-shared environmental influence was high, genetic influence was moderate, and shared environmental influence was weak-to-moderate across the connectome. The brains genetic organization is diverse and not as one would expect based solely on structure evident in non-genetically informative data or lower-resolution data. As follow-up, we make novel classifications of functional connections and examine highly-localized connections with particularly strong genetic influence. This high-resolution genetic taxonomy of brain connectivity will be useful in understanding genetic influences on brain disorders.

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Reineberg, A. E., Hatoum, A. S., Hewitt, J. K., Banich, M. T., Friedman, N. P.. 2018-03-07. Genetic and environmental influence on the human functional connectome. https://doi.org/10.1101/277996

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