A Russian validation study of the Coma Recovery Scale-Revised (CRS-R)

Mochalova, E.; Legostaeva, L.; Zimin, A.; Sergeev, D.; Domashenko, M.; Samorukov, V.; Yusupova, D.; Ryabinkina, J.; Suponeva, N.; Piradov, M.; Bodien, Y.; Giacino, J.

doi:10.1101/276881

bioRxiv · 10.1101/276881

A Russian validation study of the Coma Recovery Scale-Revised (CRS-R)

Mochalova, E.·Legostaeva, L.·Zimin, A.·Sergeev, D.·Domashenko, M.·Samorukov, V.·Yusupova, D.·Ryabinkina, J.·Suponeva, N.·Piradov, M.·Bodien, Y.·Giacino, J.

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Abstract

Introduction: The aim of the present study was to validate a Russian adaptation of the Coma Recovery Scale-Revised (CRS-R).\n\nSubjects and methods: We evaluated 58 patients diagnosed with chronic disorders of consciousness (>4 weeks post-injury, DOC) of various etiology and two patients in a locked-in state at different time points in their post-comatose recovery. We tested sensitivity for changes over 1 week, reliability, as well as criterion validity and diagnostic sensitivity of the Russian adaptation of the CRS-R in comparison with the Russian adaptations of Full Outline of UnResponsiveness Score (FOUR), and Glasgow Coma Scale (GCS).\n\nResults: We obtained good sensitivity for changes in neurological status over one week (p<0.0001) and good test-retest reliability (r=1, p<0.0001) of the CRS-R. Inter-rater reliability for the CRS-R total score ({kappa}=0.99, p<0.001) and subscale scores was good. We showed high internal consistency (=0.87 and 0.89 for the first and second visit respectively). We also showed good criterion validity between two other standardized behavioral scales (moderate correlation with GCS, r=0.597 and high correlation with FOUR Score, r=0.900). CRS-R also demonstrated a significantly higher sensitivity in differential diagnosis of DOC, as compared to GCS, and FOUR Score (p<0.001).\n\nConclusion: The results show that the Russian version of the CRS-R is a valid and sensitive tool for the evaluation of severely brain damaged patients with chronic DOC which can be used for differential diagnosis and for the assessment of dynamic recovery.

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Mochalova, E., Legostaeva, L., Zimin, A., Sergeev, D., Domashenko, M., Samorukov, V., Yusupova, D., Ryabinkina, J., Suponeva, N., Piradov, M., Bodien, Y., Giacino, J.. 2018-03-06. A Russian validation study of the Coma Recovery Scale-Revised (CRS-R). https://doi.org/10.1101/276881

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