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bioRxiv · 10.1101/272948

Collagen stiffness modulates MDA-MB231 cell metabolism through adhesion-mediated contractility

Mah, E. J.·McGahey, G. E.·Yee, A. F.·Digman, M. A.
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Abstract

O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=148 SRC=\"FIGDIR/small/272948_fig1A.gif\" ALT=\"Figure 1A\">\nView larger version (39K):\norg.highwire.dtl.DTLVardef@1529bb0org.highwire.dtl.DTLVardef@6b656borg.highwire.dtl.DTLVardef@cf7c05org.highwire.dtl.DTLVardef@1d76412_HPS_FORMAT_FIGEXP M_FIG O_FLOATNOAbstract Figure:C_FLOATNO Increasing collagen stiffness causes a shift in highly invasive MDA-MB231 cancer cells from glycolysis to oxidative phosphorylation. Glioma U251MG cells show an opposite trend and MCF10A non-tumorigenic cells have little change in metabolism signatures in response to substrates stiffness.\n\nC_FIG

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Mah, E. J., McGahey, G. E., Yee, A. F., Digman, M. A.. 2018-02-28. Collagen stiffness modulates MDA-MB231 cell metabolism through adhesion-mediated contractility. https://doi.org/10.1101/272948

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