ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

Chen, X.; Shi, X.; Hilakivi-Clarke, L.; Clarke, R.; Wang, T.-L.; Xuan, J.

doi:10.1101/260869

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bioRxiv · 10.1101/260869

ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach

Chen, X.·Shi, X.·Hilakivi-Clarke, L.·Clarke, R.·Wang, T.-L.·Xuan, J.

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Abstract

Transcription factor binding events play important functional roles in gene regulation. It is, however, a challenging task to detect weak binding events since the ambiguity in differentiation of weak binding signals from background signals. We present a software package, ChIP-BIT2, to identify weak binding events using a Bayesian integration approach. By integrating signals from sample and input ChIP-seq data, ChIP-BIT2 can detect both strong and weak binding events at gene promoter, enhancer or the whole genome effectively. The ChIP-BIT2 package has been extensively tested on ChIP-seq data, demonstrating its wide applicability in ChIP-seq data analysis.\n\nAvailability and ImplementationThe ChIP-BIT2 package is available at http://sourceforge.net/projects/chipbitc/.

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Chen, X., Shi, X., Hilakivi-Clarke, L., Clarke, R., Wang, T.-L., Xuan, J.. 2018-02-07. ChIP-BIT2: a software tool to detect weak binding events using a Bayesian integration approach. https://doi.org/10.1101/260869

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