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bioRxiv · 10.1101/260463

Education can Reduce Health Disparities Related to Genetic Risk of Obesity: Evidence from a British Reform

Barcellos, S. H.·Carvalho, L. S.·Turley, P.
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Abstract

This paper investigates whether genetic makeup moderates the effects of education on health. Low statistical power and endogenous measures of environment have been obstacles to the credible estimation of such gene-by-environment interactions. We overcome these obstacles by combining a natural experiment that generated variation in secondary education with polygenic scores for a quarter million individuals. The additional schooling affected body size, lung function, and blood pressure in middle age. The improvements in body size and lung function were larger for individuals with high genetic predisposition to obesity. As a result, education reduced the gap in unhealthy body size between those with high and low genetic risk of obesity from 20 to 6 percentage points.

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Barcellos, S. H., Carvalho, L. S., Turley, P.. 2018-02-05. Education can Reduce Health Disparities Related to Genetic Risk of Obesity: Evidence from a British Reform. https://doi.org/10.1101/260463

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