A comprehensive manually-curated Compendium of Bovine Transcription Factors

de Souza, M. M.; Vaquerizas, J. M.; Zerlotini, A.; Geistlinger, L.; Hernandez-Rodriguez, B.; Tizioto, P.; Taylor, J. F.; Rocha, M. I.; Diniz, W. J.; Coutinho, L.; Regitano, L. C. d. A.

doi:10.1101/254011

bioRxiv · 10.1101/254011

A comprehensive manually-curated Compendium of Bovine Transcription Factors

de Souza, M. M.·Vaquerizas, J. M.·Zerlotini, A.·Geistlinger, L.·Hernandez-Rodriguez, B.·Tizioto, P.·Taylor, J. F.·Rocha, M. I.·Diniz, W. J.·Coutinho, L.·Regitano, L. C. d. A.

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Abstract

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.

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de Souza, M. M., Vaquerizas, J. M., Zerlotini, A., Geistlinger, L., Hernandez-Rodriguez, B., Tizioto, P., Taylor, J. F., Rocha, M. I., Diniz, W. J., Coutinho, L., Regitano, L. C. d. A.. 2018-01-27. A comprehensive manually-curated Compendium of Bovine Transcription Factors. https://doi.org/10.1101/254011

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