-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome

Keator, D. B.; Doran, E.; VanErp, T. G. M.; Phelan, M. J.; Tseung, K.; Yassa, M. A.; Potkin, S. G.; Lott, I. T.

doi:10.1101/235440

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bioRxiv · 10.1101/235440

-Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome

Keator, D. B.·Doran, E.·VanErp, T. G. M.·Phelan, M. J.·Tseung, K.·Yassa, M. A.·Potkin, S. G.·Lott, I. T.

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Abstract

1. Background 1. Background 2. Methods 3. Results 4. Discussion 5. Conclusions References Individuals with Down syndrome (DS) have an increasing age-related prevalence of Alzheimers disease (AD). In DS, the triplication of amyloid precursor protein (APP) on chromosome 21 contributes to a life-long accumulation of brain amyloid (A{beta}) [1]. Dyshomeostasis of A{beta} has emerged as one of the most well-validated factors in the pathogenesis of AD [2]. By age 40 years, virtually all individuals with DS have amyloid plaques and tau tangles, hallmark pathologies that are characteristic of sporadic AD in the general population [3]. Dementia, while not inevitable in DS, increases significantly in prevalence with age to over 75% after age 65 years. [ ...

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Keator, D. B., Doran, E., VanErp, T. G. M., Phelan, M. J., Tseung, K., Yassa, M. A., Potkin, S. G., Lott, I. T.. 2018-02-12. -Florbetapir PET: Towards Predicting Dementia in Adults with Down Syndrome. https://doi.org/10.1101/235440

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