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bioRxiv · 10.1101/232355

Close encounters between infants and household members measured through wearable proximity sensors

Ozella, L.·Gesualdo, F.·Tizzoni, M.·Rizzo, C.·Pandolfi, E.·Campagna, I.·Tozzi, A. E.·Cattuto, C.
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Abstract

Describing and understanding close proximity interactions between infant and family members can provide key information on transmission opportunities of respiratory infections within households. Among respiratory infections, pertussis represents a public health priority. Pertussis infection can be particularly harmful to young, unvaccinated infants and for these patients, family members represent the main sources of transmission. Here, we report on the use of wearable proximity sensors based on RFID technology to measure face-to-face proximity between family members within 16 households with infants younger than 6 months for 2-5 consecutive days of data collection. The sensors were deployed over the course of approximately 1 year, in the context of a national research project aimed at the improvement of infant pertussis prevention strategies. We recorded 5,958 contact events between 55 individuals: 16 infants, 4 siblings, 31 parents and 4 grandparents. The contact networks showed a heterogeneous distribution of the cumulative time spent in proximity with the infant by family members. Most of the contacts occurred between the infant and other family members (70%), and many contacts were observed between infants and adults, in particular between infant and mother, followed by father, siblings and grandparents. A larger number of contacts and longer contact durations between infant and other family members were observed in families adopting exclusive breastfeeding, compared to families in which the infant receives artificial or mixed feeding.\n\nOur results demonstrate how a high-resolution measurement of contact matrices within infants households is feasible using wearable proximity sensing devices. Moreover, our findings suggest the mother is responsible for the large majority of the infants contact pattern, thus being the main potential source of infection for a transmissible disease. As the contribution to the infants contact pattern by other family members is very variable, vaccination against pertussis during pregnancy is probably the best strategy to protect young, unvaccinated infants.

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Ozella, L., Gesualdo, F., Tizzoni, M., Rizzo, C., Pandolfi, E., Campagna, I., Tozzi, A. E., Cattuto, C.. 2017-12-13. Close encounters between infants and household members measured through wearable proximity sensors. https://doi.org/10.1101/232355

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