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bioRxiv · 10.1101/224741

Dose response relationships for gamma radiation induced chromosomal instability

Eidelman, Y.·Slanina, S.·Pyatenko, V.·Khvostunov, I.·Andreev, S.
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Abstract

Different cell lines demonstrate various dose response for radiation-induced chromosomal instability (RICI). To clarify the origin of differences we analyzed own and published data on RICI for four cell lines, V79, TK6, WTK1 and CHO-K1 on the basis of the mechanistic RICI model. We conclude that observable dose-response shapes, both plateau-like and strong dose dependent behavior, may be jointly explained by the same model of RICI. Mechanistic modeling reveals that a variation of certain set of RICI parameters leads to strong modification of dose-response curve.

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Eidelman, Y., Slanina, S., Pyatenko, V., Khvostunov, I., Andreev, S.. 2017-11-25. Dose response relationships for gamma radiation induced chromosomal instability. https://doi.org/10.1101/224741

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