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bioRxiv · 10.1101/2025.11.19.689172

The Effects of Garlic Extract on Renal Histopathology and Function in a Cadmium Chloride-Induced Hypertension Model

Ojo, G. B.·Olorunnisola, A. A.·Adedayo, L. D.·Morakinyo, A. O.·Fakunle, R. R.·Dawodu, E. S.
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Abstract

This study investigated the antihypertensive effects of Allium sativum (garlic) on kidney function in a rat model of hypertension. Forty-eight Wistar rats were divided into groups: control, hypertensive, and hypertensive rats treated with different doses of garlic extract or a standard antihypertensive drug. Hypertension was induced by CaCl2 administration. The results demonstrated that garlic extract effectively lowered blood pressure in hypertensive rats, indicating its potential as an antihypertensive agent Further Analysis involve the histopathological examination of kidney tissues and analysis of serum electrolyte levels provided further insights into the renoprotective effects of garlic extract. This study demonstrates that garlic extract possesses antihypertensive properties in a rat model. Garlic treatment significantly lowered blood pressure compared to the hypertensive control group. Furthermore, kidney tissue analysis revealed potential renoprotective effects. These findings suggest that garlic may offer a promising complementary approach to managing hypertension. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=109 SRC="FIGDIR/small/689172v1_ufig1.gif" ALT="Figure 1"> View larger version (10K): org.highwire.dtl.DTLVardef@18c993borg.highwire.dtl.DTLVardef@19ff669org.highwire.dtl.DTLVardef@ea8614org.highwire.dtl.DTLVardef@1088c8a_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Ojo, G. B., Olorunnisola, A. A., Adedayo, L. D., Morakinyo, A. O., Fakunle, R. R., Dawodu, E. S.. 2025-11-19. The Effects of Garlic Extract on Renal Histopathology and Function in a Cadmium Chloride-Induced Hypertension Model. https://doi.org/10.1101/2025.11.19.689172

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