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bioRxiv · 10.1101/2025.11.15.688622

Autism and Schizophrenia-Associated Pcdh8 Regulates Cortical Development in Mice

Calvo Parra, S.·Barredo Paniagua, G.·Carrillo-Barbera, P.·Garcia Deante, A.·Cwetsch, A. W.
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Abstract

Defective cortical development with aberrant neuronal distribution is linked to diverse human pathologies. We show that downregulation of protocadherin-8, a cell-adhesion protein associated with autism and schizophrenia, disrupts neuronal migration and morphology, and increases proliferation in the developing mouse cortex. These findings identify protocadherin-8 as a critical determinant of cortical organization and implicate it in the potential molecular mechanisms underlying human brain pathology. Graphical abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=157 SRC="FIGDIR/small/688622v1_ufig1.gif" ALT="Figure 1"> View larger version (58K): org.highwire.dtl.DTLVardef@1dde890org.highwire.dtl.DTLVardef@1cf69c5org.highwire.dtl.DTLVardef@293bceorg.highwire.dtl.DTLVardef@1159217_HPS_FORMAT_FIGEXP M_FIG C_FIG In briefDownregulation of Pcdh8--a cell-adhesion protein linked to autism and schizophrenia-- disrupts neuronal migration and morphology and increases proliferation in the developing mouse cortex.

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Calvo Parra, S., Barredo Paniagua, G., Carrillo-Barbera, P., Garcia Deante, A., Cwetsch, A. W.. 2025-11-16. Autism and Schizophrenia-Associated Pcdh8 Regulates Cortical Development in Mice. https://doi.org/10.1101/2025.11.15.688622

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