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bioRxiv · 10.1101/2025.11.11.686736

Autonomic Indicators of Self-Transcendence: Insights from the Numadelic VR Paradigm

Bonnelle, V.·Parola, G.·Andreu, C.·Hardy, J. L.·Timmermann, C.·Cebolla, A.·Wrzesien, M.·Glowacki, D. R.
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Abstract

Self-transcendent experiences (STEs) offer profound and beneficial shifts in perspective, yet remain largely inaccessible outside elite contemplative or pharmacological contexts. Neural measures have deepened our understanding of these states, but their cost and limited ecological validity constrain broader application. This study evaluates heart rate variability (HRV) amplitude, a measure reflecting dynamic sympathovagal engagement, as a cost-effective and sustainable physiological marker of STE during numadelic virtual reality (VR) experiences. The unique numadelic aesthetic combined with multi-person can induce STE through dissolving self-boundaries and fostering embodied presence. Building on previous work linking non-ordinary states of consciousness (NOSC) with autonomic nervous system activity during psychedelic drug administration, we tested the hypothesis that HRV amplitude may reflect STE depth and relate to affective and relational outcomes during non-drug numadelic VR experiences. Specifically, ninety-six participants engaged in guided meditation within either a numadelic VR setting or a non-VR audio-guided group format. Physiological data (cardiac activity and respiration) were recorded during the meditation, alongside psychological assessments pre- and post-session. Findings confirm that HRV amplitude measured during numadelic VR correlates with subjective STE ratings. It also relates to compassion traits, and emotional improvement following VR practice. Additional analysis of data from a prior psychedelic drug study further validated the relevance of this measure across methods of inducing NOSCs. These results advance the psychophysiological mapping of STEs and highlight HRV amplitude as a potential real-time biomarker which may help to guide participants toward self-transcendent states within adaptive environments. By integrating contemplative science with immersive design, this work supports the development of scalable tools that enhance both access to and understanding of STEs.

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Bonnelle, V., Parola, G., Andreu, C., Hardy, J. L., Timmermann, C., Cebolla, A., Wrzesien, M., Glowacki, D. R.. 2025-11-12. Autonomic Indicators of Self-Transcendence: Insights from the Numadelic VR Paradigm. https://doi.org/10.1101/2025.11.11.686736

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