On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones

Mindel, V.; Barkai, N.

doi:10.1101/2025.10.12.681120

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bioRxiv · 10.1101/2025.10.12.681120

On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones

Mindel, V.·Barkai, N.

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Abstract

A recent study that systematically mapped genomic bindings and regulatory effects of transcription factors (TFs) reported a surprisingly low overlap between TF binding and regulatory targets in Saccharomyces cerevisiae1. Our analysis suggests that this conclusion depends on the permissive definition of binding targets, which includes a large fraction of weakly bound sites.

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Mindel, V., Barkai, N.. 2025-10-13. On the overlap of transcription factor binding and regulatory targets: functional and regulatory coherence of top-bound targets is masked by weakly bound ones. https://doi.org/10.1101/2025.10.12.681120

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