Prefrontal and Subcortical Value Representation during Explore-Exploit Decision-Making and Suicide Attempts

Abstract

BackgroundThis study aims to understand learning and decision-making in suicidal behavior by investigating temporal dynamics of reward value encoding in individuals with late-life depression and a history of suicide attempts. MethodsIn a retrospective case-control study, 134 older adults (33 with depression and history of suicide attempts, 29 with depression and suicidal ideation but no past attempts, 32 with depression and no suicidal ideation/past attempts, and 40 psychiatrically healthy controls) completed an explore-exploit decision-making task during functional MRI (fMRI). Multilevel models of deconvolved fMRI time series, time-locked to trial events, interrogated whether temporal patterns of reward value encoding was associated with suicidal behavior. ResultsSuicidal behavior in general was associated with blunted ventral PFC (vPFC) value signals, but profiles varied as a function of attempt lethality. Specifically, low-lethality suicide attempts and excessive behavioral shifts were associated with abolished phasic responses to value updates in the default network vPFC and its connected regions, including the striatum, amygdala, and hippocampus. Additionally, an unexpected pattern of sustained negative value responses was observed in vPFC and striatal control subregions, and hippocampus of high-lethality suicide attempters. ConclusionsDiverging patterns of decision-related responses may reflect different paths toward suicidal behavior. Impaired value updating in individuals with low-lethality suicide attempts suggests a failure to integrate recent outcomes alongside prior experience, potentially relating to over-reactivity to stressors and a lower threshold for suicide attempts. In contrast, increased control network responses to difficult choices in high-lethality attempters may underlie cognitive constriction and consideration of a narrow set of potential solutions.