Neuronal signatures of successful one-shot memory in mid-level visual cortex

Abstract

High-capacity, one-shot visual recognition memory challenges theories of learning and neural coding because it requires rapid, robust, and durable representations. Most studies have focused on the hippocampus and other higher areas. However, behavioral evidence demonstrating links between image properties and memorability and revealing image specificity of visual memory suggests an important role for mid-level visual cortex. We tested the hypothesis that area V4 contains signals that could support recognition memory. Our task increased difficulty, allowing comparisons of neuronal population responses on correct and error trials. We observed signatures of several proposed memory mechanisms including magnitude coding, repetition suppression, sparse coding, and population response consistency, but only sparse coding and population response consistency predicted behavior. Familiar images also evoked faster dynamics, consistent with pattern completion. These findings demonstrate that the building blocks of fast, high-capacity memory are present in mid-level sensory cortex, highlighting its role in distributed memory networks.