Immunometabolic state modulation of sequential decision making in patch-foraging mice

Lau, D.; Gagnon, P.; La Fay, A.; Palmer, D.; Boisjoly, F.; Majeur, D.; Manceau, R.; Nakajima, S.; Robb, J.; Zeighami, Y.; Fulton, S.

doi:10.1101/2025.09.07.674667

bioRxiv · 10.1101/2025.09.07.674667

Immunometabolic state modulation of sequential decision making in patch-foraging mice

Lau, D.·Gagnon, P.·La Fay, A.·Palmer, D.·Boisjoly, F.·Majeur, D.·Manceau, R.·Nakajima, S.·Robb, J.·Zeighami, Y.·Fulton, S.

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Abstract

Animals have evolved sophisticated behavioural and metabolic adaptations to respond to threats to homeostasis, including resource scarcity and infectious pathogens. Energy deficits associated with lack of food availability and sickness-associated anorexia elicit distinctive hypometabolic states, however how such states are integrated with higher-order cognition is largely unknown. Patch-foraging paradigms have proven useful for deciphering evolutionarily conserved and ethologically grounded insights into cost-benefit decision-making as animals continually deliberate between exploiting and exploring their environment. We developed and extensively validated a touchscreen-based patch-foraging task for mice in which food reward dynamically varied across trials, in a dataset comprising over 111,000 sequential decisions from 35 adult male mice. Contrary to predictions that emphasize the impact of inflammation to blunt effortful reward-driven behaviour, our results demonstrate that systemic lipopolysaccharides-induced inflammation promotes hyper-exploitation by attenuating exploratory choice behaviour in animals interacting with complex food environments. Such behaviour can be seen as a bias towards immediate outcomes, with impulsivity as a feature affecting the weighting of temporal factors. Given the ubiquity of systemic inflammation in numerous infectious, metabolic and psychiatric disorders featuring dysfunctional value- and cost-sensitive behaviour, these results provide insight into how immunometabolic states are linked to altered decision-making.

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Lau, D., Gagnon, P., La Fay, A., Palmer, D., Boisjoly, F., Majeur, D., Manceau, R., Nakajima, S., Robb, J., Zeighami, Y., Fulton, S.. 2025-09-12. Immunometabolic state modulation of sequential decision making in patch-foraging mice. https://doi.org/10.1101/2025.09.07.674667

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