Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

Koubele, J.; Beyer, A.

doi:10.1101/2025.08.24.672013

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bioRxiv · 10.1101/2025.08.24.672013

Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data

Koubele, J.·Beyer, A.

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Abstract

We present a computational method to jointly estimate changes in the elongation speed of RNA Polymerase II, and the speed of intron splicing, using total RNA-seq. An implementation of our method is available at https://github.com/jkoubele/pol-ii-speed.

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Koubele, J., Beyer, A.. 2025-08-28. Estimating changes in RNA Polymerase II elongation and intron splicing speeds from total RNA-seq data. https://doi.org/10.1101/2025.08.24.672013

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