Contrasting roles of host species in tick-pathogen interactions and their influence on Lyme borreliosis hazard across boreal island communities

Wand, Y. X. G.; Kiran, N.; Brila, I.; Kesaniemi, J.; Sipari, S.; Tukalenko, E.; Vuorenmaa, S.; Welsh, E.; Fenton, A.; Mappes, T.; Kallio, E. R.

doi:10.1101/2025.08.21.671197

bioRxiv · 10.1101/2025.08.21.671197

Contrasting roles of host species in tick-pathogen interactions and their influence on Lyme borreliosis hazard across boreal island communities

Wand, Y. X. G.·Kiran, N.·Brila, I.·Kesaniemi, J.·Sipari, S.·Tukalenko, E.·Vuorenmaa, S.·Welsh, E.·Fenton, A.·Mappes, T.·Kallio, E. R.

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Abstract

Predicting the hazard of Lyme borreliosis (LB) is complex due to host-specific effects on tick and pathogen dynamics. To unpick the contributions of cervids and rodents on ticks and Borrelia burgdorferi infection in ticks in boreal region, we analysed data from 41 islands in Finland (2017-2021) with considerable natural variation in the abundances of cervids and rodents, and densities of nymphs (DON: 0-82.5 nymphs/100 m2), nymph infection prevalences (NIP: 0-60%) and densities of infected nymphs (DIN: 0-16.5/100 m2). Using structural equation modelling (SEM), we disentangled direct and indirect effects of host abundances on LB hazard (i.e., DIN). Rodent abundance was associated with higher DIN through its positive effect on NIP (pathogen amplification), while showing no effect on DON. Cervids increased DON (vector amplification) but decreased NIP (pathogen dilution). Our study suggests that in boreal forests the vectors may be supported by very low cervid densities and, as a virtual absence of rodents did not eliminate the pathogen, the pathogen is likely to persist through very low rodent densities. Our study highlights how islands function as a natural mesocosm for rigorous field studies of complex ecological interactions and SEM can serve as a powerful tool to reveal mechanisms driving LB hazard.

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Wand, Y. X. G., Kiran, N., Brila, I., Kesaniemi, J., Sipari, S., Tukalenko, E., Vuorenmaa, S., Welsh, E., Fenton, A., Mappes, T., Kallio, E. R.. 2025-08-23. Contrasting roles of host species in tick-pathogen interactions and their influence on Lyme borreliosis hazard across boreal island communities. https://doi.org/10.1101/2025.08.21.671197

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