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bioRxiv · 10.1101/2025.08.15.670570

Prehistoric Global Migration of Vanishing Gut Microbes With Humans

Abstract

The gut microbiome is crucial for health and greatly affected by lifestyle. Many microbes common in non-industrialized populations are disappearing or extinct in industrialized populations. Understanding which microbes have been long-term residents of the human gut, and may have co-evolved with humans, has implications for the importance of microbial biodiversity loss for health. However, the genetic complexities of microbial evolution and the plasticity of gut microbiome composition have made it challenging to define these long-term associations. Here, we performed deep metagenomic sequencing of the Tsimane horticulturalists of Bolivia and compared their gut microbiomes with the Hadza hunter-gatherers of Tanzania. These two populations, whose ancestors were separated for tens of thousands of years, share 1,231 microbial species, most of which are absent in industrialized populations. Population genetic analyses in 636 of these shared species revealed patterns of microbial divergence and gene flow consistent with prehistoric human co-migration, with estimated split times that approximately align with human migration out of Africa and into the Americas. Our findings indicate that a diverse gut microbiome co-migrated with humans around the globe, persisting over millennia. However, many of these species are now vanishing in industrialized populations, and the consequences for human health remain uncertain.

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BibTeXRIS

Carter, M. M., Liu, Z., Olm, M. R., Martin, M., Sprockett, D. D., Trumble, B. C., Kaplan, H., Stieglitz, J., Rodriguez, D. E., Relman, D. A., Sonnenburg, E. D., Gurven, M., Good, B. H., Sonnenburg, J. L.. 2025-08-15. Prehistoric Global Migration of Vanishing Gut Microbes With Humans. https://doi.org/10.1101/2025.08.15.670570

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