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bioRxiv · 10.1101/2025.08.15.670500

Shipped and shifted: modeling collection-induced bias in microbiome multi-omics using a tractable fermentation system

Abstract

Large-scale, decentralized microbiome sampling surveys and citizen science initiatives often require periods of storage at ambient temperature, potentially altering sample composition during collection and transport. We developed a generalizable framework to quantify and model these biases using sourdough as a tractable fermentation system, with samples subjected to controlled storage conditions (4 {degrees}C, 17 {degrees}C, 30 {degrees}C, regularly sampled up to 28 days). Machine-learning models paired with multi-omics profiling -- including microbiome, targeted and untargeted metabolome profiling, and cultivation -- revealed temperature-dependent shifts in bacterial community structure and metabolic profiles, while fungal communities remained stable. Storage induced ecological restructuring, marked by reduced network modularity and increased centrality of dominant taxa at higher temperatures. Notably, storage duration and temperature were strongly encoded in the multi-omics data, with temperature exerting a more pronounced influence than time. 24 of the top 25 predictors of storage condition were metabolites, underscoring functional layers as both sensitive to and informative of environmental exposure. These findings demonstrate that even short-term ambient storage (< 2 days) can substantially reshape microbiome, metabolome, and biochemical profiles, posing risks to data comparability in decentralized studies and emphasizing the need to recognize and address such biases. Critically, the high predictability of storage history offers a path toward bias detection and correction -- particularly when standardized collection protocols are infeasible, as is common in decentralized sampling contexts. Our approach enables robust quantification and modeling of such storage effects across multi-omics datasets, unlocking more accurate interpretation of large-scale microbiome surveys.

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BibTeXRIS

Meyer, A. R., Tan, J., Mihaila, M., Neugebauer, M., Nystroem, L., Bokulich, N.. 2025-08-15. Shipped and shifted: modeling collection-induced bias in microbiome multi-omics using a tractable fermentation system. https://doi.org/10.1101/2025.08.15.670500

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