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bioRxiv · 10.1101/2025.08.14.670362

Depression symptoms enhance goal-directed behavior underuncertainty

Abstract

A core premise in decision-making research is that beliefs about uncertain outcomes shape value-based choice: pessimistic expectations should reduce goal pursuit, whereas optimistic expectations should promote it. Depression provides a critical test of this assumption, as motivational symptoms such as apathy and anhedonia are linked to diminished expectations of success. Yet whether such biases actually impair goal-directed behavior, particularly when risk must be learned from experience, remains unknown. We developed a multi-step planning task in which participants (n = 384) learned the structure and risks of maze-like environments across two days, then chose between certain rewards and risky goals varying in reward magnitude and distance, with greater distance entailing higher compounding risk. Using transdiagnostic symptom factors, we observed a dissociation: individuals with elevated apathy-anhedonia reported lower subjective expectations of goal success, yet showed no reduction in risky goal pursuit. Instead, higher apathy-anhedonia was associated with enhanced performance, including stronger discrimination of goal values, increased model-based flexibility, and faster goal navigation. These effects were specific to apathy-anhedonia; other symptom factors, including worry and impulsivity, were unrelated to expectations or goal-directed behavior. Together, these findings demonstrate that pessimistic beliefs and goal-directed competence are dissociable, revealing that motivational symptoms can coexist with sharpened value-based planning when risk is learned from experience.

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BibTeXRIS

Liang, S., Russek, E. M., Rutledge, R., Wimmer, G. E.. 2025-08-19. Depression symptoms enhance goal-directed behavior underuncertainty. https://doi.org/10.1101/2025.08.14.670362

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