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bioRxiv · 10.1101/2025.08.10.669538

Generalized brain-state modeling with KenazLBM

Abstract

The large-scale functional state of a human brain remains difficult to characterize, much less predict. Regardless, techniques have been engineered to electrically neuromodulate the brain to treat a subset of neurologic and psychiatric disorders with moderate efficacy. Accurate characterization of a brains instantaneous functional state has stymied the development of more effective neuromodulation paradigms. Advanced computational methods are required to address this gap and enable large-scale neuroscience. Here we define the concept of generalized brain-state modeling across humans as Large Brain-State Modeling (LBM) and present KenazLBM as the worlds first example. KenazLBM can instantaneously characterize the functional state of a persons brain with raw iEEG data, and predict future brain-states. KenazLBM was trained on over 17.9 billion unique multichannel tokens from people undergoing intracranial electroencephalography (iEEG) recordings, and has learned to interrelate brain-states between people into a common interpretable topology. Most importantly, the model generalizes to unseen subject data with significant recording channel heterogeneity from the training set. We offer KenazLBM as a first generalized brain-state model to serve as a new paradigm of basic neuroscience inquiry and potential translation into neuromodulation therapeutics.

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BibTeXRIS

Johnson, G. W., Makhoul, G., Doss, D., Hidalgo, B., Cai, L., Liao, E., Paulo, D., Reda, A., Withers, C. P., Cavender, A., Qian, H., Obiri-Yeboah, D., Mensah-Brown, K., Kerezoudis, P., Baker, M., Jensen, M., Reddy, S., Roberson, S. W., Crudele, A., Naftel, R., Hermes, D., Hawkes, M., Kremen, V., Bydon, M., Ali, R., Lee, K., Lanzino, G., Bick, S., Van Gompel, J., Constantinidis, C., Morgan, V., Marsh, R., Zadeh, G., Worrell, G., Miller, K., Englot, D.. 2025-08-12. Generalized brain-state modeling with KenazLBM. https://doi.org/10.1101/2025.08.10.669538

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