Behavioural and physiological evidence for the development of cardiac-exteroceptive integration during the first year of life

Isomura, T.; Suga, A.; Kobayashi, M.; Terasawa, Y.; Kimura, K.; Ohira, H.

doi:10.1101/2025.07.31.668000

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bioRxiv · 10.1101/2025.07.31.668000

Behavioural and physiological evidence for the development of cardiac-exteroceptive integration during the first year of life

Isomura, T.·Suga, A.·Kobayashi, M.·Terasawa, Y.·Kimura, K.·Ohira, H.

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Abstract

Continuous integration of environmental exteroceptive and internal interoceptive signals is fundamental for perception and adaptive behaviours, yet its developmental trajectory remains poorly understood. Here, we introduced a modified iBEATs paradigm, based on prior work, to investigate cardiac-exteroceptive integration in 3-8-month-old infants. Using behavioural measures of looking time and physiological measures of pupillometry, we found that the ability to detect cardiac-exteroceptive synchrony emerges during the first year of life. Critically, this was evident only when stimuli coincided with systole, the baroreceptor-active phase of the cardiac cycle, supporting central multimodal integration interpretable within a predictive coding framework. Furthermore, individual differences in behavioural sensitivity were accounted for by the degree of autonomic maturation. These findings provide the first evidence for the developmental emergence and mechanisms of cardiac-exteroceptive integration, and establish the modified iBEATs paradigm as a promising tool for assessing interoceptive development in early life.

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Isomura, T., Suga, A., Kobayashi, M., Terasawa, Y., Kimura, K., Ohira, H.. 2025-08-01. Behavioural and physiological evidence for the development of cardiac-exteroceptive integration during the first year of life. https://doi.org/10.1101/2025.07.31.668000

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