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bioRxiv · 10.1101/2025.07.29.667406

Striatal pathways oppositely shift cortical activity along the decision axis

Abstract

The cortex and basal ganglia are organized into multiple parallel loops that serve motor, limbic, and cognitive functions. The classic model of cortico-basal ganglia interactions posits that within each loop, the direct pathway of the basal ganglia activates the cortex and the indirect pathway inhibits it1-3. While this model has found support in the motor domain4,5, whether opponent control by the two pathways extends to the cognitive domain remains unknown. Here, we record from anterior cingulate cortex (ACC) and dorsomedial striatum (DMS) while inhibiting direct or indirect pathway neurons in DMS, as mice perform an accumulation-of-evidence task6-10. Inconsistent with the classic model, the manipulations do not produce opponent changes in overall ACC activity. Instead, the pathways exert opponent influence over a subpopulation of ACC neurons that encode accumulated sensory evidence, the task-relevant decision variable. The direction of the modulation depends on a neurons tuning to ipsilateral versus contralateral evidence, such that the two pathways generate opponent shifts in coding specifically along the decision axis. Thus, our results uncover unexpected specificity in the effects of basal ganglia pathways on the cortex, with the two pathways of the DMS exerting opponent control not on overall activity but on coding of the relevant task variable. This functional specificity may extend to other basal ganglia loops to support different aspects of adaptive behavior, with the pathways serving a general role in selecting and shifting cortical representations to subserve circuit-specific functions.

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BibTeXRIS

Cho, J. R., Bolkan, S. S., Brown, L. S., Skuza, M., El-Jayyousi, Y., Midler, B., Fetcho, R. N., Zimmerman, C. A., Pan-Vazquez, A., Schottdorf, M., Bondy, A. G., Sanchez, M. A., Lopez Luna, J. F., Luna, A., Eilers, T., Kalmbach, A. S., Lu, Y., Lynch, L. A., Witten, I.. 2025-07-30. Striatal pathways oppositely shift cortical activity along the decision axis. https://doi.org/10.1101/2025.07.29.667406

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