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bioRxiv · 10.1101/2025.07.25.666732

Pathway-Centric Visualization of Cell-Cell Communication in Single-Cell Transcriptomics Data

Maryam, S.·Manolov, M.·Kramann, R.·Hayat, S.
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Abstract

ObjectiveSingle-nuclei transcriptomics enables investigating ligand-receptor mediated cell-cell communication between different cell-types. However, current tools do not allow for non-programmatic means to access this analysis. Additionally, most methods can not account for molecular pathways involved in downstream receptor signaling in cell-cell communication. MethodsWe developed scVizComm, a ShinyApp based web-portal that can be used to interactively visualize ligand-receptor networks across cell-types and different conditions. ResultsscVizComm can be used to host pathway centric pre-calculated cell-cell communication results. Using human kidney and heart single-nuclei transcriptomics data, we showcase the utility of scVizComm in understanding ligand-receptor interactions involved in fibrosis related pathways. ConclusionscVizComm allows interactive visualisation and pathway centric prioritisation of cell-cell communication analyses.

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Maryam, S., Manolov, M., Kramann, R., Hayat, S.. 2025-07-30. Pathway-Centric Visualization of Cell-Cell Communication in Single-Cell Transcriptomics Data. https://doi.org/10.1101/2025.07.25.666732

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