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bioRxiv · 10.1101/2025.07.09.663763

Connectivity and function are coupled across cognitive domains throughout the brain

Hiersche, K.·Saygin, Z.·Osher, D. E.
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Abstract

Decades of neuroimaging have revealed that the functional organization of the brain is roughly consistent across individuals and at rest it is resembles group-level task-evoked networks. A fundamental assumption in the field is that the functional specialization of a brain region arises from its connections to the rest of the brain, but limitations in the amount of data that can be feasibly collected in a single individual, leaves open the question: Is the association between task activation and connectivity consistent across the brain and many cognitive tasks? To answer this question, we fit ridge regressions models to activation maps from 33 cognitive domains (generated with NeuroQuery) using resting-state functional connectivity data from the Human Connectome Project as the predictor. We examine how well functional connectivity fits activation and find that all regions and all cognitive domains have a very robust relationship between brain activity and connectivity. The tightest relationship exists for higher-order, domain-general cognitive functions. These results support the claim that connectivity is a general organizational principle of brain function by comprehensively testing this relationship in a large sample of individuals for a broad range of cognitive domains and provide a reference for future studies engaging in individualized predictive models.

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Hiersche, K., Saygin, Z., Osher, D. E.. 2025-07-14. Connectivity and function are coupled across cognitive domains throughout the brain. https://doi.org/10.1101/2025.07.09.663763

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