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bioRxiv · 10.1101/2025.07.01.662569

Homoeolog expression in polyploid wheat mutants shows limited transcriptional compensation

Dorussen, D.·Knight, E.·Simmonds, J.·Borrill, P.
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Abstract

Active transcriptional compensation between gene duplicates (paralogs or homoeologs) has been proposed to facilitate functional redundancy, whereby mutations in multiple gene copies are required before a phenotype is observed. We tested whether transcriptional compensation occurs between homoeologs in response to premature termination codon (PTC) mutations in mutagenised wheat lines. Only [~]3% of cases showed homoeologous upregulation in response to PTC mutations, suggesting that there is no widespread active transcriptional compensation between wheat homoeologs.

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Dorussen, D., Knight, E., Simmonds, J., Borrill, P.. 2025-07-02. Homoeolog expression in polyploid wheat mutants shows limited transcriptional compensation. https://doi.org/10.1101/2025.07.01.662569

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