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bioRxiv · 10.1101/2025.06.26.661882

Serosurveillance Studies of Peste des Petits Ruminants (PPR) Virus in Sheep and Goats in South Asia: A Systematic Review and Meta-analysis

Ahmed, M. J.·Hossain, M. I.·Chalise, R.·Rahman, M. A.·Bhandari, P.·Sikder, T.·Khatun, A.·Hossain, D.
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Abstract

BackgroundPeste des Petits Ruminants (PPR), also known as the goat plague, is one of the WOAH-listed A, highly contagious and economically important viral transboundary animal diseases affecting small ruminants, and having a significant impact on the global livestock industry and international animal traffic. ObjectiveThe present study aimed to use a systematic approach to assess the pooled seroprevalence of PPRV in sheep and goats in South Asia, through a systematic review and meta-analysis of published data. MethodsA thorough search on various databases was performed to identify published research articles published between January 2000 and June 2025 reporting the seroprevalence of PPRV in small ruminants in South Asia. The articles were chosen on the basis of specific inclusion and exclusion criteria. Since the heterogeneity among the studies was significant, the pooled seroprevalence was estimated via a random effects meta-analysis model, using Stata (v19) and R software (v4.5.0). ResultsIn sheep and goats, the estimated pooled seroprevalence of PPR was 42.4% (95% CI: 35.0-49.9), whereas it was 41.8% (95% CI: 33.7-50.1) in goats and 44.5% (95% CI: 37.0- 52.0) in sheep. Subgroup analysis revealed that the pooled seroprevalence of PPRV in sheep and goat by country and vaccination status was greater in Nepal (57.0%, 95% CI: 8.4-97.7) and in vaccinated animals (57.5%, 95% CI: 47.9-66.9). ConclusionThis study highlights the need for coordinated actions, including vaccination, surveillance, and strict biosecurity, to control and eradicate the disease effectively. Moreover, authorities should adopt evidence-based strategies to support the global goal of eradicating PPR by 2030, as recommended by the WOAH.

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Ahmed, M. J., Hossain, M. I., Chalise, R., Rahman, M. A., Bhandari, P., Sikder, T., Khatun, A., Hossain, D.. 2025-06-27. Serosurveillance Studies of Peste des Petits Ruminants (PPR) Virus in Sheep and Goats in South Asia: A Systematic Review and Meta-analysis. https://doi.org/10.1101/2025.06.26.661882

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