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bioRxiv · 10.1101/2025.06.19.659671

Cellulase secretion by engineered Pseudomonas putida enables growth on cellulose oligomers.

Abstract

Pseudomonas putida is an attractive synthetic biology platform organism for chemical synthesis from low-grade feedstocks due to its high tolerance to chemical solvents and lignin-derived small molecules that are often inhibitory to other biotechnologically relevant microorganisms. However, there are few molecular tools available for engineering P. putida and other gram-negative bacteria to secrete non-native enzymes for extracellular feedstock depolymerisation. In this study P. putida was transformed to secrete cellulase enzymes and evaluated for growth on polymeric or oligomeric cellulose substrates. Active exo- and endocellulase enzymes were secreted into the culture supernatant, and a preferred set of twin-arginine translocase secretion signal peptides were identified. Extracellular cellulase activity was sufficient to support growth of P. putida using cellotriose or cellotetraose as the sole source of carbon and energy. This work supports progress towards consolidated bioprocessing of cellulosic materials using P. putida, and advances the state of engineered protein secretion in gram negative bacteria. Key PointsO_LIEngineered Pseudomonas putida secreted cellulase enzymes into the culture medium C_LIO_LICellulase activity was sufficient to support growth on cellulose oligomers C_LI

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BibTeXRIS

Smith, M. R., Moffitt, K., Holdsworth, W., Luna-Flores, C. H., Goyal, M., Beliaev, A., Speight, R. E., Behrendorff, J. B.. 2025-06-20. Cellulase secretion by engineered Pseudomonas putida enables growth on cellulose oligomers.. https://doi.org/10.1101/2025.06.19.659671

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