The cost of cognition: Measuring the energy consumption of non-equilibrium computation

Abstract

In biological systems, survival is predicated on an animal being able to perform computations quickly on a minimal energy budget. What is the energy consumption of non-equilibrium brain computation, i.e., what is the cost of cognition? Previous literature has estimated the metabolic cost using neuroimaging measures of glucose consumption but complementary to these findings, here we directly estimate the computational costs by combining the new field of stochastic thermodynamics with whole-brain modelling. We developed the COCO (COst of COgnition) framework using an analytical expression quantifying the links between energy cost, non-equilibrium and information processing for any given brain state measured with neuroimaging. Importantly, this key relationship also holds at the level of individual brain regions. We used this to quantify the benefits of information processing on the highly anatomically, interconnected hierarchical systems of the brain. Crucially, in empirical neuroimaging data we demonstrate that the human brain uses significantly less energy overall than other mammals (including non-human primates and mice), suggestive of an evolutionary optimisation of the effectiveness of computation. Focusing on the cost of cognition, using large-scale human neuroimaging data of 970 healthy human participants, we show that the resting state uses significantly less energy that seven different cognitive tasks. Furthermore, different kinds of tasks require different amounts of non-equilibrium, information processing and energy consumption. We found that tasks requiring more distributed computation also use more energy. Overall, these results directly quantify the cost of cognition, i.e., the non-equilibrium and energetic demands of information processing, allowing a deeper understanding of how the brain compute in a way that is far more energy efficient than current generations of digital computers and artificial intelligence.