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bioRxiv · 10.1101/2025.06.18.660316

Urological benchtop and in silico models validated by human penile tissue inflation tests

Akbarzadeh Khorshidi, M.·Bose, S.·Watschke, B.·Mareena, E.·Sinnott, T.·Lally, C.
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Abstract

PurposeInflatable penile prosthesis (IPP) implantation is a well-established treatment for erectile dysfunction (ED). A comprehensive understanding of the mechanical interactions between the IPP and penile tissues is crucial for improving surgical outcomes and device performance. This study aims to develop and validate preclinical testbeds, including a polymer-based benchtop model and a finite element (FE) model, to replicate the biomechanical behaviour of penile tissues during IPP inflation. MethodsA polymer-based benchtop model was developed using porous and non-porous polyvinyl alcohol (PVA) hydrogels, with the porous PVA mimicking the spongy corpus cavernosum (CC) and the non-porous PVA representing the tunica albuginea (TA) and fascial layers. IPP inflation tests were conducted on three benchtop models and three human penile tissue segments. Additionally, 3D FE simulations of IPP inflation were performed on both the benchtop and human tissue models for comparative analysis. ResultsThe experimental results demonstrated strong agreement between the human penile tissues, the benchtop model, and the FE simulations, validating the preclinical testbeds. Parametric studies using the FE model revealed that CC layer size and stiffness significantly influence IPP inflation mechanics, highlighting the importance of these factors in device performance. These validated preclinical testbeds provide a robust platform for optimising IPP design, guiding surgical procedures, and mitigating post-implantation complications associated. ConclusionThe developed benchtop and FE models effectively replicate human penile tissue responses to IPP inflation and can serve as valuable preclinical tools for device manufacturers and clinicians. Their use may enhance surgical decision-making and improve long-term IPP outcomes.

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Akbarzadeh Khorshidi, M., Bose, S., Watschke, B., Mareena, E., Sinnott, T., Lally, C.. 2025-06-24. Urological benchtop and in silico models validated by human penile tissue inflation tests. https://doi.org/10.1101/2025.06.18.660316

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