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bioRxiv · 10.1101/2025.06.13.657723

S3Mirror: Making Genomic Data Transfers Fast, Reliable, and Observable with DBOS

Vasquez-Grinnell, S.·Poliakov, A.
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Abstract

To meet the needs of a large pharmaceutical organization, we set out to create S3Mirror - an application for transferring large genomic sequencing datasets between S3 buckets quickly, reliably, and observably. We used the DBOS-Transact durable execution framework to achieve these goals and benchmarked the performance and cost of the application. S3Mirror is an open source DBOS Python application that can run in a variety of environments, including DBOS Cloud Pro where it runs as much as 40x faster than AWS DataSync at a fraction of the cost. Moreover, S3Mirror is resilient to failures and allows for real-time file-wise observability of ongoing and past transfers.

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Vasquez-Grinnell, S., Poliakov, A.. 2025-06-16. S3Mirror: Making Genomic Data Transfers Fast, Reliable, and Observable with DBOS. https://doi.org/10.1101/2025.06.13.657723

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