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bioRxiv · 10.1101/2025.06.05.658105

Ambient Pollution Components and Sources Associated with Hippocampal Architecture and Memory in Pre-Adolescents

Abstract

BackgroundAmbient air pollution poses significant risks to brain health. The hippocampus may be particularly vulnerable, yet the extent to which it is impacted in children remains unclear. MethodsUsing partial least squares correlation, we cross-sectionally analyzed air pollution, brain, and cognitive data from the Adolescent Brain Cognitive Development Study to examine how multi-pollutant exposure influences hippocampal structure and memory in 9-11-year-olds (n= 7,940). Annual average air pollution exposures included PM2.5 (total mass, 15 components, and 6 source factors), NO2, and 8-hour maximum O3. Hippocampal outcomes included microstructure measured using Restriction Spectrum Imaging and hippocampus longitudinal-axis (i.e., head, body, tail) volumes. We examined hippocampal-dependent list-learning using the Rey Auditory Verbal Learning Test. Models were adjusted for demographic, socioeconomic, and neuroimaging factors. FindingsPM2.5 total mass was associated with hippocampal microstructure, but not long-axis volume or list-learning ability. Component and source analyses provided greater specificity: higher bromine, sulfate, and vanadium exposure was related to microstructure (72% shared variance), while higher copper and zinc exposure correlated with smaller left head and right body and tail volumes (75% shared variance). Source models implicated biomass burning and traffic pollution in microstructure (61% and 32% shared variance) and industrial and traffic sources in smaller hippocampal volumes (77% shared variance). Higher exposure to several components were also linked to poorer list-learning (67% shared variance). DiscussionCo-exposure to multiple pollutants is linked to differences in hippocampal structure and memory, showing that associations are driven not only by PM2.5 total mass but also by specific components and sources. This evidence underscores the necessity of targeting source-specific (e.g., biomass burning, traffic, and industrial emissions) and constituent components (e.g., metals) of air pollution during critical developmental windows to safeguard brain health.

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BibTeXRIS

Rosario, M. A., Sukumaran, K., Bottenhorn, K. L., de Jesus, A., Cardenas-Iniguez, C., Ahmadi, H., Habre, R., Abad, S., Pine, J. G., Barch, D. M., Schwartz, J., Hackman, D. A., Chen, J.-C., Herting, M. M.. 2025-06-09. Ambient Pollution Components and Sources Associated with Hippocampal Architecture and Memory in Pre-Adolescents. https://doi.org/10.1101/2025.06.05.658105

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