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bioRxiv · 10.1101/2025.06.04.657853

Left Area PF as a Neural Marker of Technical Reasoning

Federico, G.·Ilardi, C. R.·Marangolo, P.·Bryche, C.·Metaireau, M.·Bluet, A.·Lesourd, M.·Rossetti, Y.·Osiurak, F.
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Abstract

Humans possess a unique capacity for technical reasoning--the ability to infer and manipulate the causal structure of the physical world. Although this faculty is central to technological innovation, its neural substrates remain incompletely understood. Here, we show that grey matter volume in the left cytoarchitectonic area PF, within the supramarginal gyrus of the inferior parietal lobule, selectively predicts and accurately classifies technical reasoning performance in healthy adults (N = 75; 54 females; mean age = 20.92 {+/-} 3.28 years). This association persists independently of demographic factors, personality traits, and total brain volume. By contrast, grey matter volume in right prefrontal regions, examined as control areas, correlates with broader cognitive functions--namely, fluid intelligence and abstract reasoning, but not with technical reasoning. These findings support the hypothesis that the left area PF is a domain-specific substrate for technical reasoning. Situated within a parietal territory that is evolutionarily expanded in humans, this region may constitute a neural signature of the human capacity to understand and reshape the material world.

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Federico, G., Ilardi, C. R., Marangolo, P., Bryche, C., Metaireau, M., Bluet, A., Lesourd, M., Rossetti, Y., Osiurak, F.. 2025-06-08. Left Area PF as a Neural Marker of Technical Reasoning. https://doi.org/10.1101/2025.06.04.657853

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