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bioRxiv · 10.1101/2025.06.02.657368

Evolution's boldest trick: Neurotransmission modulated whole-brain computation captures full task repertoire

Abstract

The perhaps most important unsolved problem in neuroscience is how the brain survives in a complex world by performing a rich repertoire of computation on a minimal energy budget. The brain is much better at adapting to the multiplicity of stimuli and outcomes than current generations of computers, artificial neural deep learning and reservoir model architectures. Yet, at first glance the brain appears to use a fixed anatomical architecture to perform the necessary huge variety of computations. But evolutions boldest trick is that in fact the brains effective connectivity is constantly being updated through neuromodulation to allow the rich repertoire of computation. Inspired by this, we created a whole-brain model using empirical neurotransmitter maps modulating the underlying local regional dynamics. This NEMO (neurotransmission modulated) whole-brain model is able to flexibly compute the full task repertoire and associated functional connectivity of the neuroimaging data from 971 healthy participants. For each individual we defined a measure of brain computability as the fitting of the NEMO whole-brain model to all tasks performed by the individual. Importantly, brain computability correlates with both behavioural performance on individual tasks and with a general behavioural measure of intelligence. Overall, our proposed unifying NEMO framework offers a natural way to sculpt different brain dynamics in a fixed brain architecture to compute the rich repertoire of tasks required for surviving and thriving.

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BibTeXRIS

Deco, G., Sanz Perl, Y., Vohryzek, J., Luppi, A., Kringelbach, M. L.. 2025-06-03. Evolution's boldest trick: Neurotransmission modulated whole-brain computation captures full task repertoire. https://doi.org/10.1101/2025.06.02.657368

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