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bioRxiv · 10.1101/2025.05.29.656932

Immunomodulatory Biomaterials Enhancing Implant Osseointegration: Knowledge Mapping of Research Evolution from March 2005 to March 2025

Li, Y.·Liu, G.
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Abstract

ObjectiveTo delineate the evolutionary trajectory of immunomodulatory biomaterials in implant osseointegration through bibliometric analysis, identifying pivotal theoretical breakthroughs and technological advancements. MethodsA total of 419 articles (2005-2025) from the Web of Science Core Collection were analyzed using a multi-tool framework. Current research status and hotspots were evaluated by co-occurrence analysis of keywords and institutions using VOSviewer. The evolution and bursts of the knowledge base were assessed through co-citation analysis of references, authors, and journals via CiteSpace. Thematic evolution and keyword trends were mapped using the bibliometrix package in R. ResultsThe field exhibited "intermittent-explosive" growth (32.7% annual increment), with China leading global contributions (69.4%). The osteoimmunomodulation (OIM) theory emerged as the cornerstone, emphasizing spatiotemporal macrophage polarization (M1/M2 balance) and multi-signal crosstalk (BMP-2/VEGF/OSM). Key technological pathways included: [circled1] Surface engineering (nanotopography, ion-doped coatings); [circled2] Smart materials (3D-printed scaffolds, pH/ROS-responsive carriers); [circled3] Antibacterial-immunomodulatory synergy. Burst detection revealed shifting frontiers toward clinical translation (2023-2025 burst: "3D printing", strength=4.05) and precision modulation ("macrophage polarization", strength=9.02). ConclusionImmunomodulatory biomaterials are transitioning from mechanistic exploration to clinical adaptation. Future development requires integrating dynamic microenvironment-responsive designs with multi-omics validation to address macrophage heterogeneity, ultimately enabling personalized osseointegration therapies.

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Li, Y., Liu, G.. 2025-06-01. Immunomodulatory Biomaterials Enhancing Implant Osseointegration: Knowledge Mapping of Research Evolution from March 2005 to March 2025. https://doi.org/10.1101/2025.05.29.656932

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