An open, fully-processed data resource for studying mood and sleep variability in the developing brain

Brook, J. B. H.; Salo, T.; Luo, A. C.; Bagautdinova, J.; Rush, S.; Alexander-Bloch, A. F.; Baller, E. B.; Calkins, M. E.; Cieslak, M.; Cooper, E. C.; Detre, J. A.; Elliot, M. A.; Fair, D. A.; Freedman, P.; Gehrman, P. R.; Gur, R. C.; Gur, R. E.; Klein, A.; Laney, N.; Laumann, T. O.; Mehta, K.; Merikangas, K.; Milham, M. P.; Mitchell, J. A.; Moore, T. M.; Nelson, S. M.; Ruparel, K.; Sevchik, B. L.; Shanmugan, S.; Shou, H.; Taso, M.; White, L. K.; Wolf, D. H.; Tisdall, D.; Roalf, D. R.; Satterthwaite, T. D.

doi:10.1101/2025.05.01.651544

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bioRxiv · 10.1101/2025.05.01.651544

An open, fully-processed data resource for studying mood and sleep variability in the developing brain

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Abstract

Brain development during adolescence and early adulthood coincides with shifts in emotion regulation and sleep. Despite this, few existing datasets simultaneously characterize affective dynamics, sleep variation, and multimodal measures of brain development. Here, we describe the study protocol and initial release (n = 10) of an open data resource of neuroimaging paired with densely sampled behavioral measures in adolescents and young adults. All participants complete multi-echo functional MRI, compressed-sensing diffusion MRI, and advanced arterial spin-labeled MRI. Behavioral measures include ecological momentary assessment, actigraphy, extensive cognitive assessments, and detailed clinical phenotyping focused on emotion regulation. Raw and processed data are openly available without a data use agreement and will be regularly updated as accrual continues. Together, this resource will accelerate research on the links between mood, sleep, and brain development.

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Brook, J. B. H., Salo, T., Luo, A. C., Bagautdinova, J., Rush, S., Alexander-Bloch, A. F., Baller, E. B., Calkins, M. E., Cieslak, M., Cooper, E. C., Detre, J. A., Elliot, M. A., Fair, D. A., Freedman, P., Gehrman, P. R., Gur, R. C., Gur, R. E., Klein, A., Laney, N., Laumann, T. O., Mehta, K., Merikangas, K., Milham, M. P., Mitchell, J. A., Moore, T. M., Nelson, S. M., Ruparel, K., Sevchik, B. L., Shanmugan, S., Shou, H., Taso, M., White, L. K., Wolf, D. H., Tisdall, D., Roalf, D. R., Satterthwaite, T. D.. 2025-05-02. An open, fully-processed data resource for studying mood and sleep variability in the developing brain. https://doi.org/10.1101/2025.05.01.651544

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