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bioRxiv · 10.1101/2025.04.29.651306

Microglia Mitochondria Drive Neuronal Maturation via Metabolic and Transcriptional Reprogramming

Sterben, S. P.·Anamala, C. C.·Koduri, V.·Kansakar, S. B.·Liaudanskaya, V.
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Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interactions, repetitive behaviors, and disrupted neuronal circuit maturation. Emerging evidence implicates both microglial function and mitochondrial regulation as critical determinants of ASD pathogenesis. Here, we identified microglia and their mitochondria as active modulators of neuronal circuit development, highlighting their potential roles as mechanistic contributors and biomarkers in ASD progression. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=147 SRC="FIGDIR/small/651306v1_ufig1.gif" ALT="Figure 1"> View larger version (44K): org.highwire.dtl.DTLVardef@6794ddorg.highwire.dtl.DTLVardef@5e71cborg.highwire.dtl.DTLVardef@80f0acorg.highwire.dtl.DTLVardef@138c828_HPS_FORMAT_FIGEXP M_FIG C_FIG

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Sterben, S. P., Anamala, C. C., Koduri, V., Kansakar, S. B., Liaudanskaya, V.. 2025-04-30. Microglia Mitochondria Drive Neuronal Maturation via Metabolic and Transcriptional Reprogramming. https://doi.org/10.1101/2025.04.29.651306

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