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bioRxiv · 10.1101/2025.04.27.650870

MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Ghamei, B.·Rosu, A.·Kuddannaya, S.·Laurent, G.·Bazzi, R.·Roux, S.·Sakeri-Zadeh, A.·Bulte, J.
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Abstract

Intratumoral nanoparticle (NP) injection is a commonly used for local hyperthermia. A limitation of this delivery route is the limited NP dispersion and retainment within the tumor, with undesired leakage leading to off-target toxicity. By exploiting their inherent tumor tropism, we have used human mesenchymal stem cells (hMSCs) as delivery vehicles for magnetic theranostic gold-iron oxide nanoflowers (GIONF) to improve their overall intratumoral distribution and retention. GIONF-loaded hMSCs exhibited excellent heating properties for laser photothermal therapy and high tracer performance for visualization and quantification by magnetic particle imaging (MPI). In contrast to naked GIONF, GIONF-hMSCs remained within the prostate tumors one week post-injection, with MPI-guided PTT completely ablating tumors without recurrence.

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Ghamei, B., Rosu, A., Kuddannaya, S., Laurent, G., Bazzi, R., Roux, S., Sakeri-Zadeh, A., Bulte, J.. 2025-04-30. MPI-Guided Photothermal Therapy of Prostate Cancer using Stem Cell Delivery of Magnetotheranostic Nanoflowers. https://doi.org/10.1101/2025.04.27.650870

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