c-MYC can Form Phase Condensates via its DNA Binding Domain

Vijayakumar, U.; Choudhary, R.; Chng, W. J.; Fullwood, M. J.

doi:10.1101/2025.04.22.650002

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bioRxiv · 10.1101/2025.04.22.650002

c-MYC can Form Phase Condensates via its DNA Binding Domain

Vijayakumar, U.·Choudhary, R.·Chng, W. J.·Fullwood, M. J.

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Abstract

The c-MYC oncogene is overexpressed in cancers. Phase condensates are membrane-less cellular compartments in cells. Using the optoDroplet system, which leverages optogenetics for condensate dynamics studies, here we showed c-MYC has the capability to form phase condensates. Moreover, the 3 terminus of c-MYC, which contains a DNA binding domain but no intrinsic disordered regions, is sufficient to form phase condensates. Our research contributes to a better understanding of c-MYC biology.

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Vijayakumar, U., Choudhary, R., Chng, W. J., Fullwood, M. J.. 2025-04-25. c-MYC can Form Phase Condensates via its DNA Binding Domain. https://doi.org/10.1101/2025.04.22.650002

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