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bioRxiv · 10.1101/2025.04.16.649217

Speech markers of psychedelic-induced psychological change

Kuc, J.·McAlpine, R. G.·Sellers, A.·Blackburne, G.·Lametti, D.·Skipper, J. I.
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Abstract

5-MeO-DMT, a potent, short-acting psychedelic, induces profound shifts in cognition, affect, and self-awareness. Because language explicitly expresses these domains and voice implicitly conveys them, both may serve as potential biomarkers of behavioural change. This study introduces a novel framework for analysing baseline language and vocal features, pre- to post-psychedelic changes, assessing their potential to predict subjective experiences and psychological outcomes. Daily voice journals from 29 participants were collected via RetreatBot for two weeks before and after 5-MeO-DMT (1x12 mg). Transcripts were analysed using NLP (bag-of-words for vocabulary; transformer model for textual affect), and acoustic features (e.g., pitch, jitter, shimmer) were extracted to assess vocal dynamics. Following 5-MeO-DMT, speech markers revealed increased cognitive language, decreased social words, and altered voice quality (increased jitter/shimmer). Baseline speech patterns predicted psychological preparedness, ego dissolution anxiety, emotional breakthrough, and post-experience well-being. This first longitudinal analysis of speech markers following psychedelic use demonstrates a shift from external focus to introspection. Speech markers predicted and tracked psychological transformation, establishing vocal journaling as a valuable framework for monitoring psychedelic-induced changes and facilitating integration.

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Kuc, J., McAlpine, R. G., Sellers, A., Blackburne, G., Lametti, D., Skipper, J. I.. 2025-04-21. Speech markers of psychedelic-induced psychological change. https://doi.org/10.1101/2025.04.16.649217

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