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bioRxiv · 10.1101/2025.04.13.648378

Slow Gompertzian aging in long-lived C. elegans results from expansion of decrepitude, not decelerated aging

Zhang, B.·Gems, D.
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Abstract

The Gompertz equation describes exponential age-increases in animal mortality rate arising from biological aging. Its parameters, and {beta}, are widely used to evaluate lifespan-extending interventions and human mortality patterns: it is assumed that reduction in {beta} corresponds to deceleration of aging rate, and reduction in to reduced aging-independent mortality. However, this view has never been empirically validated. We therefore investigated the biological basis of and {beta}, by simultaneous quantification of mortality and age-related health in long-lived populations of the nematode Caenorhabditis elegans. We show that reduction in {beta} arises not from decelerated aging but expansion of decrepitude in longer-lived individuals, whereas reduction in arises from decelerated aging. This empirical re-evaluation of Gompertzian aging inverts and challenges long-standing ideas in the biodemography of aging.

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Zhang, B., Gems, D.. 2025-04-18. Slow Gompertzian aging in long-lived C. elegans results from expansion of decrepitude, not decelerated aging. https://doi.org/10.1101/2025.04.13.648378

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