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bioRxiv · 10.1101/2025.04.05.646688

Robin: An Advanced Tool for Comparative Loop Caller Result Analysis Leveraging Large Language Models

Chowdhury, H. M. A. M.·Fuller, M.·Oluwadare, O. E.
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Abstract

BackgroundThere has been significant interest in genomics research, leading to the development of numerous new methods. One notable area of progress is in chromosome looping detection algorithms (also known as loop callers). However, despite these advancements, there is no available platform to analyze, compare, or benchmark current tools results on the go. Developing such a platform is crucial to accelerate research and ensure the reliability and effectiveness of new methods in the field. ResultsHence, in this work, we propose Robin, an advanced ready-to-go platform for comparative loop caller result analysis leveraging Large Language Models (LLMs). Robin is a web server designed to analyze loop caller results, offering a comprehensive range of analysis metrics such as recovery and overlap. It is integrated with HiGlass and incorporates LLMs to enable users to generate plots simply by providing instructions. ConclusionsOverall, Robin is a robust and comprehensive loop caller result analysis and visualization tool. It is publicly accessible at http://hicrobin.online, with a comprehensive documentation available at http://documentation.hicrobin.online/.

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Chowdhury, H. M. A. M., Fuller, M., Oluwadare, O. E.. 2025-04-09. Robin: An Advanced Tool for Comparative Loop Caller Result Analysis Leveraging Large Language Models. https://doi.org/10.1101/2025.04.05.646688

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