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bioRxiv · 10.1101/2025.03.19.644260

3D printing cytoskeletal networks: ROS-induced filament severing leads to surge in actin polymerization

Abstract

The cytoskeletal protein actin forms a spatially organized biopolymer network that plays a central role in many cellular processes. Actin filaments continuously assemble and disassemble, enabling cells to rapidly reorganize their cytoskeleton. Filament severing accelerates actin turnover, as both polymerization and depolymerization rates depend on the number of free filament ends. Here, we use light to control actin severing in vitro by locally generating reactive oxygen species (ROS) with photosensitive molecules such as fluorophores. We see that ROS sever actin filaments, which increases actin polymerization in our experiments. However, beyond a certain threshold, excessive severing leads to the disassembly of actin networks, allowing us to selectively remove actin structures. Our experimental data is supported by simulations using a kinetic model of actin polymerization, which helps us understand the underlying dynamics. In cells, ROS are known to regulate the actin cytoskeleton, but the molecular mechanisms are poorly understood. Here we show that, in vitro, ROS directly affect actin reorganization.

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Litschel, T., Vavylonis, D., Weitz, D. A.. 2025-03-20. 3D printing cytoskeletal networks: ROS-induced filament severing leads to surge in actin polymerization. https://doi.org/10.1101/2025.03.19.644260

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