Human pulvinar stimulation engages select cortical pathways in epilepsy

Bilderbeek, J. A.; Gregg, N. M.; Yanez-Ramos, M. G.; Huang, H.; Montoya, M. M.; Brunner, P.; Willie, J. T.; Van Gompel, J. J.; Worrell, G. A.; Miller, K. J.; Hermes, D.

doi:10.1101/2025.03.11.642694

bioRxiv · 10.1101/2025.03.11.642694

Human pulvinar stimulation engages select cortical pathways in epilepsy

Bilderbeek, J. A.·Gregg, N. M.·Yanez-Ramos, M. G.·Huang, H.·Montoya, M. M.·Brunner, P.·Willie, J. T.·Van Gompel, J. J.·Worrell, G. A.·Miller, K. J.·Hermes, D.

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Abstract

The pulvinar has been proposed as an effective neuromodulation target for patients with posterior quadrant and temporal epilepsies. However, the pulvinar has a large tissue volume, multiple subnuclei, and widespread cortical connections. It remains unknown whether electrical stimulation of distinct pulvinar subregions affects the temporal, occipital, and parietal areas differently. To address this gap, we delivered single-pulse electrical stimulation to the pulvinar and measured the resulting brain stimulation evoked potentials in twelve patients undergoing stereotactic EEG for drug-resistant epilepsy. Brain stimulation evoked potentials were parameterized across the occipital, temporal and parietal cortex. Stimulation of the lateral pulvinar elicited significant brain stimulation evoked potentials in striate and extrastriate areas that diminish as stimulation shifts towards the medial pulvinar. Conversely, stimulation of the ventral aspect of the medial pulvinar produced significant lateral temporal evoked potentials, which diminish with lateral pulvinar stimulation. We also found that stimulation of the dorsomedial pulvinar evoked significant parietal responses with limited striate/extrastriate and lateral temporal responses. These results demonstrate that electrical stimulation of specific pulvinar subregions influences distinct occipital, parietal and lateral temporal areas. Selective targeting of pulvinar subregions to maximize seizure network engagement may be essential for individualized treatment of posterior quadrant and temporal epilepsies.

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Bilderbeek, J. A., Gregg, N. M., Yanez-Ramos, M. G., Huang, H., Montoya, M. M., Brunner, P., Willie, J. T., Van Gompel, J. J., Worrell, G. A., Miller, K. J., Hermes, D.. 2025-03-13. Human pulvinar stimulation engages select cortical pathways in epilepsy. https://doi.org/10.1101/2025.03.11.642694

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